Only insofar as you allow dirt, lint, grit and other foreign matter to hide away in the USB port. You could always cover it over with a piece of Scotch tape if you're really worried. Remove and replace, as needed.
It really depends more on how clean you and your clothes are. A kid, for example, would probably have mud caked in it after a day. A businessman in a suit would have no more threat the lint from a coat pocket. If your keys are stored in a purse (or that camera bag), then it could be perfectly fine, and there's absolutely nothing to worry about.
My drives sit open almost 24/7, because they never move much out of the office.
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