If the audio is mixed into the same channels, no, that's not possible.
Some dubbings, however -- many retail VCDs, for example -- stored separate audio in left and right channels. The left would be something like English, while the right would be Mandarin or French or whatever. In this case, it was easy to extract the content from the disc, demux the audio+video streams back to elementary form, and then load the audio in an editor like
Sound Forge. In SF, you'd delete the unwanted channel, and then clone the "good" channel onto the now-blank channel. Then re-save the audio and re-create the VCD. Or DVD, or AVI, or whatever it is/was.
For a freeware audio editor, look at Audacity.
