I would second what Lordsmurf said. Please get Vuescan. It's been years since I did print scanning with an Epson, and negative/slide scanning with Pacific Image Primefilm XE scanner. But in both cases, Vuescan was a far superior experience, and what I used to scan everything with. You need something that allows you to select the region you want to scan. Since I abandoned other software, I cannot recall if there is even an option to do so with Epson's software. If you must stay with Epson's software, all I can suggest is try to find an advanced scanning mode of some kind that allows user to move the edges of the lines shown (or to draw the box around the area) before you scan.
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