That's a doom9 sort of topic.
I'm a user, rarely programmer. No clue. Maybe?
I generally just 2-pass (or more) my Avisynth, if possible. It's all saved lossless anyway. 32-bit, 64-bit, maybe 32 again. Or vice versa. Yes, it takes longer. But then again, sometimes stacking filter actually takes longer than just multi-running the Avisynth sessions.