Avidemux is mostly junk now, lots of bugs for the past decade.
The sole value in it is to encode to MPEG-2 -- but DVD-Video specs only, it does lack options for better broadcast-depth settings like 4:2:2 and bitrates. It's a very narrow implementation of ffmpeg. I wish selur could add MPEG to Hybrid, but he's not familiar with it, and my coding chops are a decade out of date now (and were never great, I was mostly a reverse engineer for hacking/modding).
Honestly, anybody that recommended Avidemux in 2025 is probably somebody that should not be taken seriously as a knowledgeable user. They're just parroting outdated suggestions.
Hybrid is an amazing tool, the "Swiss knife" of typical encoding needs and filtering.
The member @selur has done an amazing job, and I've honestly never met a better independent freeware dev. Never, not in 35 years of downloading freeware (yes, that includes even BBS days). He deserves not just praise, but a
donation (scroll to bottom).
--- But don't forget this site, it needs funding too!.
The GUI needs some work, it's very "IT/engineering" obtuse at times. Not so user friendly, not a candy-coated newbie tool. But ask. selur will help, I'll help, others will help. It just looks daunting, but it's really quite easy*. (*When you learn to ignore most of the detailed settings that you'll rarely use, but are invaluable when you do).
Avisynth is not an encoder, and is purely a scripted language, a go-between for the source file and the encoder software. Instead of opening the video, you open the Avisynth script file (.avs), assuming the encoder knows how to handle it. Many do not, but it's because they are either too basic, or NLEs.
VERDICT = use Hybrid.